Before validation starts the method should be documented with an instruction in Your laboratory. Write down a detailed procedure how to operate the method in your lab. In appendix A of the Eurachem Guide you find the following most important headings: 

 

Method instruction

Determination of x in matrices z,y, in the concentration range from ...

1     Scope

           (Scope, application, measuring interval, limitations etc)

2    References

                  (ISO standards, manuals, other SP methods)

3     Principle

                    (Sample preparation, measuring principle, reactions – short text)

4     HSE – health, safety and environment

5     Limitations

                    (Conditions, interferences, important info)

6    Equipment

                  (Premises, instrument, balances, ovens, glass)

7    Chemicals and reagents

                  (Ref material, chemicals, solutions with expiry date, QC samples)

8    Sample

                   (Sample description, subsampling, sample treatment)

9    Procedure

                  (Analysis, calibration, parameter settings in programs, quality control

10    Calculation and reporting

                    (calculation of result, computer programs, reporting of results, significant digits

11    Version control

                     Version No

                     Comment

12    Annexes